The Role of Kisspeptins (KiSS-1) in Breast Cancer Therapy: the Essential Kiss of Life

The most common malignancy among Indian women is breast cancer. Patient’s ages ranging between 35 40 yrs old at diagnosis are usually considered as the endangered population [1].Breast cancer in women below 40 years is not a usual condition. However, a sudden increase in the incidence of breast cancers in premenopausal women has been reported from several countries. Though adjuvant combination chemotherapy has made immense progress, still about 50% of all women with resected early breast carcinoma suffer from relapse [2]. Systemic dissemination of tumour cells results into most of breast cancer-related deaths rather than primary tumour growth. Detachment from the primary site, survival in the circulation, attachment to and invasion of distant tissues (intravasation), proliferation and angiogenesis at the secondary sites (extravasation) are the various steps which has to take place for the metastatic spread of malignant cells [3].This mechanisms of metastasis development have been studied for several years.